The onset of effect is approximately 20 minutes, with complete effect usually seen within 90 minutes.Ĭare should be taken to completely reverse digoxin in patients who are chronically taking digoxin, as reversal may exacerbate their underlying disease. The typical DSFab infusion is over 30 minutes, but it may be given as a bolus for critical patients. (Digoxin level (steady state) x Weight (kg))/100 = Number vials of DSFab for acute or chronic overdoseĭSFab fragments also can be given for poisoning with natural toxins, but the dosing is unclear.
(0.8 times the ingested dose)/0.5 = Number of vials of DSFab for acute overdose Digoxin Concentration greater than 10 ng/mL measured 6 hours post-ingestion.Įmpiric dosing of DSFab can be given at a dose of ten to 20 vials for critically ill patients after acute overdose, three to six vials for chronic toxicity in adults, or one to two vials for chronic toxicity in children.
0 kommentar(er)
